Search results for "interaction [hadron hadron]"

Conceptual design and simulation of a water Cherenkov muon veto for the XENON1T experiment

2014

XENON is a direct detection dark matter project, consisting of a time projection chamber (TPC) that uses xenon in double phase as a sensitive detection medium. XENON100, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, is one of the most sensitive experiments of its field. During the operation of XENON100, the design and construction of the next generation detector (of ton-scale mass) of the XENON project, XENON1T, is taking place. XENON1T is being installed at LNGS as well. It has the goal to reduce the background by two orders of magnitude compared to XENON100, aiming at a sensitivity of $2 \cdot 10^{-47} \mathrm{cm}^{\mathrm{2}}$ for a WIMP mass of 50 GeV/c$^{2}$. With…

Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent

2013

Human 70 kDa heat shock protein (hHsp70) is an ATP-dependent chaperone and is currently an important target for developing new drugs in cancer therapy. Knowledge of the conformations of hHsp70 is central to understand the interactions between its nucleotide-binding domain (NBD) and substrate-binding domain (SBD) and is a prerequisite to design inhibitors. The conformations of ADP-bound (or nucleotide-free) hHsp70 and ATP-bound hHsp70 was investigated by using unbiased all-atom molecular dynamics (MD) simulations of homology models of hHsp70 in explicit solvent on a timescale of .5 and 2.7 μs, respectively. The conformational heterogeneity of hHsp70 was analyzed by computing effective free-e…

Novel structural insights into F-actin-binding and novel functions of calponin homology domains.

2008

Tandem calponin homology (CH) domains are well-known actin filaments (F-actin) binding motifs. There has been a continuous debate about the details of CH domain-actin interaction, mainly because atomic level structures of F-actin are not available. A recent electron microscopy study has considerably advanced our structural understanding of CH domain:F-actin complex. On the contrary, it has recently also been shown that CH domains can bind other macromolecular systems: two CH domains from separate polypeptides Ncd80, Nuf2 can form a microtubule-binding site, as well as tandem CH domains in the EB1 dimer, while the single C-terminal CH domain of alpha-parvin has been observed to bind to a alp…

Experimental evaluation of topological-based fitness functions to detect complexes in PPI networks

2012

The detection of groups of proteins sharing common biological features is an important research issue, intensively investigated in the last few years, because of the insights it can give in understanding cell behavior. In this paper we present an extensive experimental evaluation campaign aiming at exploring the capability of Genetic Algorithms (GAs) to find clusters in protein-protein interaction networks, when different topological-based fitness functions are employed. A complete experimentation on the yeast protein-protein interaction network, along with a comparative evaluation of the effectiveness in detecting true complexes on the yeast and human networks, reveals GAs as a feasible an…

Emotions, Motives, Individuals, and Cultures in Interaction

2016

Cognitive aspects of the human mind form the foundations of solving usability problems. However, being able to use a technology is not the only critical psychological question in the design of successful HTI. In addition to understanding users’ capabilities, it is equally important to comprehend their preferences and what they want to accomplish with the help of technologies. Knowledge of the dynamic mind—in particular human emotions, motives, and personality—helps address such ‘liking and wanting’ concerns in HTI design.

Controlling the wetting properties of the Asakura-Oosawa model and applications to spherical confinement.

2012

We demonstrate for the Asakura-Oosawa model and an extension of this model that uses continuous rather than hard potentials, how wetting properties at walls can be easily controlled. By increasing the interaction range of the repulsive wall potential acting on the colloids (while keeping the polymer-wall interactions constant) polymers begin to substitute colloids at walls and the system can be driven from complete wetting of colloids via partial wetting to complete wetting of polymers. As an application, we discuss the morphology and wetting behavior of colloid-polymer mixtures in spherical confinement. We apply the recently developed 'ensemble switch method' where the Hamiltonian is exten…

Restricted Neighborhood search clustering revisited: an evolutionary computation perspective

2013

Socio-emotional Experience in Human Technology Interaction Design – A Fashion Framework Proposal

2021

Technology designers and developers can be understood as social experience (SE) mediators. In user experience (UX), notions of SE have served to identify and define the factors contributing to human-technology interaction (HTI). Three dominant perspectives have been promoted in UX discourse: 1) SE of brand, brand value and consumer culture; 2) technology design as mediator of human-to-human interactions; and 3) meaning generation through action and interaction between actors. Symbolic interactionalism understands meaning as occurring through dialogue, in the construction of the social self, promoting self-reflection as a social construction. This theorisation of social experience is valuabl…

Towards Experiencing Eating as a Form of Play

2018

There is an increasing trend in interaction design to engage with food. We note that most prior work targets instrumental benefits (for example see food tracking apps to manage nutritional intake). In contrast, in this article, we highlight the potential of technology to support eating as a form of play. We reflect on our own work to articulate two design strategies for game designers on how they can facilitate playful eating experiences using novel technologies. Ultimately, with our work, we aim to facilitate a more playful engagement around the way we eat.

L‐Aspartate as a high‐quality nitrogen source in Escherichia coli : Regulation of L‐aspartase by the nitrogen regulatory system and interaction of L‐…

2020

Escherichia coli uses the C4-dicarboxylate transporter DcuA for L-aspartate/fumarate antiport, which results in the exploitation of L-aspartate for fumarate respiration under anaerobic conditions and for nitrogen assimilation under aerobic and anaerobic conditions. L-Aspartate represents a high-quality nitrogen source for assimilation. Nitrogen assimilation from L-aspartate required DcuA, and aspartase AspA to release ammonia. Ammonia is able to provide by established pathways the complete set of intracellular precursors (ammonia, L-aspartate, L-glutamate, and L-glutamine) for synthesizing amino acids, nucleotides, and amino sugars. AspA was regulated by a central regulator of nitrogen meta…